Genetic and epigenetic factors in the regulation of the immune response.

ABSTRACT:

Purpose of review

The review will update readers on research examining the influence of genetic variation and epigenetics on the immune system and whether genetic variation influences the outcome of critically ill children.

Recent findings

Although there have been few recent studies examining the role of genetic variation in the severity of disease or outcome in critically ill children, studies in critically ill adults have been informative. For example, genetic variations in the genes coding for various components of the immune response, such as the Toll-like receptor 1, interleukin-1RA, proprotein convertase subtilisin/kexin type 9, adoponectin, nuclear factor erythroid 2-related factor 2, elafin, sphingosine 1-phosphate receptor 3, and sushi, von Willebrand factor type A,

SUBMITTER: Dahmer MK 

PROVIDER: S-EPMC6508538 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature