Ontology highlight
ABSTRACT:
SUBMITTER: Madhavan M
PROVIDER: S-EPMC6508550 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature methods 20180725 9
Cerebral organoids provide an accessible system for investigations of cellular composition, interactions, and organization but have lacked oligodendrocytes, the myelinating glia of the central nervous system. Here we reproducibly generated oligodendrocytes and myelin in 'oligocortical spheroids' derived from human pluripotent stem cells. Molecular features consistent with those of maturing oligodendrocytes and early myelin appeared by week 20 in culture, with further maturation and myelin compac ...[more]