Opportunities and barriers for pragmatic embedded trials: Triumphs and tribulations.

ABSTRACT:

Results

Embedded pragmatic clinical trials (PCTs) are set in routine health care, have broad eligibility criteria, and use routinely collected electronic data. Many consider them a breakthrough innovation in clinical research and a necessary step in clinical trial development. To identify barriers and success factors, we reviewed published embedded PCTs and interviewed 30 researchers and clinical leaders in 7 US delivery systems.

Literature

We searched PubMed, the Cochrane library, and clinicaltrials.gov for studies reporting embedded PCTs. We identified 108 embedded PCTs published in the last 10 years. The included studies had a median of 5540 randomized patients, addressed a variety of diseases, and practice settings covering a broad range of interventions. Eighty-one used

SUBMITTER: Ramsberg J 

PROVIDER: S-EPMC6508852 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature