Survival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost.

ABSTRACT:

Background

Posterior fossa ependymoma (PFE) comprises 2 groups, PF group A (PFA) and PF group B (PFB), with stark differences in outcome. However, to the authors' knowledge, the long-term outcomes of PFA ependymoma have not been described fully. The objective of the current study was to identify predictors of survival and neurocognitive outcome in a large consecutive cohort of subgrouped patients with PFE over 30 years.

Methods

Demographic, survival, and neurocognitive data were collected from consecutive patients diagnosed with PFE from 1985 through 2014 at the Hospital for Sick Children in Toronto, Ontario, Canada. Subgroup was assigned using genome-wide methylation array and/or immunoreactivity to histone H3 K27 trimethylation (H3K27me3).

Results

A total of 72 PFE

SUBMITTER: Zapotocky M 

PROVIDER: S-EPMC6508980 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature