Magnetic resonance imaging of noradrenergic neurons.

ABSTRACT: Noradrenaline is a neurotransmitter involved in general arousal, selective attention, memory, inflammation, and neurodegeneration. The purpose of this work was to delineate noradrenergic neurons in vivo by T₁-weighted MRI with magnetization transfer (MT). In the brainstem of human and mice, MRI identified the locus coeruleus, dorsal motor vagus nucleus, and nucleus tractus solitarius. Given (1) the long T₁ and low magnetization transfer ratio for the noradrenergic cell groups compared to other gray matter, (2) significant correlation between MT MRI signal intensity and proton density, and (3) no correlation between magnetization transfer ratio (or R₁) and iron, copper, or manganese in human brain, the high MRI signal of the noradrenergic neurons must be att

SUBMITTER: Watanabe T 

PROVIDER: S-EPMC6509075 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature