Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study.

ABSTRACT:

Aims/hypothesis

Individuals with type 2 diabetes have an altered bacterial composition of their gut microbiota compared with non-diabetic individuals. However, these alterations may be confounded by medication, notably the blood-glucose-lowering biguanide, metformin. We undertook a clinical trial in healthy and previously drug-free men with the primary aim of investigating metformin-induced compositional changes in the non-diabetic state. A secondary aim was to examine whether the pre-treatment gut microbiota was related to gastrointestinal adverse effects during metformin treatment.

Methods

Twenty-seven healthy young Danish men were included in an 18-week one-armed crossover trial consisting of a pre-intervention period, an intervention period and a post-intervention period

SUBMITTER: Bryrup T 

PROVIDER: S-EPMC6509092 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature