Variability and directionality of inferior olive neuron dendrites revealed by detailed 3D characterization of an extensive morphological library.

ABSTRACT: The inferior olive (IO) is an evolutionarily conserved brain stem structure and its output activity plays a major role in the cerebellar computation necessary for controlling the temporal accuracy of motor behavior. The precise timing and synchronization of IO network activity has been attributed to the dendro-dendritic gap junctions mediating electrical coupling within the IO nucleus. Thus, the dendritic morphology and spatial arrangement of IO neurons governs how synchronized activity emerges in this nucleus. To date, IO neuron structural properties have been characterized in few studies and with small numbers of neurons; these investigations have described IO neurons as belonging to two morphologically distinct types, "curly" and "straight". In this work we collect a large number of ind

SUBMITTER: Vrieler N 

PROVIDER: S-EPMC6509097 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature