Safety of Opioids in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

We aimed to assess the safety of opioids in the management of osteoarthritis (OA) in a systematic review and meta-analysis of randomized, placebo-controlled trials.

Methods

A comprehensive literature search was undertaken in the MEDLINE, Cochrane Central Register of Controlled Trials (Ovid CENTRAL), and Scopus electronic databases. Randomized, double-blind, placebo-controlled, parallel-group trials that assessed adverse events (AEs) with opioids in patients with OA were eligible for inclusion. Two authors appraised titles, abstracts and full-text papers for suitability and then assessed the studies for random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data and selective out

SUBMITTER: Fuggle N 

PROVIDER: S-EPMC6509215 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature