Prediction and characterisation of lantibiotic structures with molecular modelling and molecular dynamics simulations.

ABSTRACT: Lantibiotics are lanthionine-containing bactericidal peptides produced by gram-positive bacteria as a defence mechanism against other bacterial species. Lantipeptides disrupt the integrity of target cells by forming pores in their cell membranes, or by preventing cell wall biosynthesis, which subsequently results in cell death. Lantibiotics are of immense importance to the food preservation and pharmaceutical industries. The rise in multidrug resistance demands the discovery of novel antimicrobials, and several authors advocate that lantibiotics hold the future of antimicrobial drug discovery. Owing to their amenability to structural modifications, novel lantibiotics with higher efficacy and antimicrobial activity can be constructed by bioengineering and nanoengineering strategies, and is

SUBMITTER: Chakraborty HJ 

PROVIDER: S-EPMC6509333 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature