Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis.

ABSTRACT: Background Toll-like receptor ( TLR ) 9 recognizes bacterial DNA , activating innate immunity, whereas it also provokes inflammation in response to fragmented DNA released from mammalian cells. We investigated whether TLR 9 contributes to the development of vascular inflammation and atherogenesis using apolipoprotein E-deficient ( Apoe ^-/-) mice. Methods and Results Tlr9-deficient Apoe ^-/- ( Tlr9 ^-/- Apoe ^-/-) mice and Apoe ^-/- mice on a Western-type diet received subcutaneous angiotensin II infusion (1000 ng/kg per minute) for 28 days. Angiotensin II increased the plasma level of double-stranded DNA, an endogenous ligand of TLR 9, in these mice. Genetic deletion or pharmacologic blockade of TLR 9 in angiotensin II-infused Apoe ^-/

SUBMITTER: Fukuda D 

PROVIDER: S-EPMC6509720 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature