Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample.

ABSTRACT:

Background

Few studies have examined the relationships between sputum inflammatory markers and subsequent annual decline in forced expiratory volume in 1 s (dFEV₁). This study investigated whether indices of airway inflammation are predictors of dFEV₁ in a general population-based sample.

Methods

The study, conducted from 2003 to 2005, included 120 healthy Norwegian subjects aged 40 to 70 years old. At baseline, the participants completed a self-administered respiratory questionnaire and underwent a clinical examination that included spirometry, venous blood sampling, and induced sputum examination. From 2015 to 2016, 62 (52%) participants agreed to a follow-up examination that did not include induced sputum examination. Those with a FEV₁/for

SUBMITTER: Kononova N 

PROVIDER: S-EPMC6509765 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature