Low expression of ACLY associates with favorable prognosis in acute myeloid leukemia.

ABSTRACT:

Background

Aberrant metabolism is a hallmark of cancer cells. Recently, ATP citrate-lyase (ACLY) expression was demonstrated as an independent predictor of clinical outcome in solid tumors. However, no systematic study was conducted to explore the prognostic impact of ACLY on acute myeloid leukemia (AML).

Methods

To assess the prognostic value of ACLY transcript, we conducted a study with a discovery and validation design. We measured ACLY transcript by real-time quantitative PCR in 274 AML patients, and validated the prognostic value in the two independent cohorts using published data. Meta-analysis of gene-expression profile and inhibition ACLY expression in leukemia cell lines were conducted to help us understand the biological insight of low ACLY expression.

Results</

SUBMITTER: Wang J 

PROVIDER: S-EPMC6509777 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature