Age-associated decrease in de novo donor-specific antibodies in renal transplant recipients reflects changing humoral immunity.

ABSTRACT:

Background

Older age at organ transplantation is associated with increased risk of infection and malignancy but reduced risk of cellular rejection. De novo donor-specific anti-HLA antibodies (dnDSA), are key biomarkers associated with reduced long-term allograft survival, yet there is a lack of data focusing on age-associated changes.

Methods

Development of dnDSA was restrospectively analyzed in all subjects who received a kidney transplant at the University Hospital Zurich between 01/2006 and 02/2015. Follow up continued until 03/2016. The incidence of dnDSA in different age categories was compared with special focus on the extremes of age: children < 10 years (n = 19) and adults ≥60 years of age (n = 110).

Results

Incidence of d

SUBMITTER: von Moos S 

PROVIDER: S-EPMC6509825 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature