Screening drug target combinations in disease-related molecular networks.

ABSTRACT:

Background

For treating a complex disease such as cancer, some effective means are needed to control biological networks that underlies the disease. The one-target one-drug paradigm has been the dominating drug discovery approach in the past decades. Compared to single target-based drugs, combination drug targets may overcome many limitations of single drug target and achieve a more effective and safer control of the disease. Most of existing combination drug targets are developed based on clinical experience or text-and-trial strategy, which cannot provide theoretical guidelines for designing and screening effective drug combinations. Therefore, systematic identification of multiple drug targets and optimal intervention strategy needs to be developed.

Results

We developed a

SUBMITTER: Luo M 

PROVIDER: S-EPMC6509874 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature