Associations of Phthalates and Phthalate Replacements With CRH and Other Hormones Among Pregnant Women in Puerto Rico.

ABSTRACT:

Context

Phthalates are endocrine-disrupting chemicals that may be associated with adverse birth outcomes. Dysregulation of maternal endocrine homeostasis could be a possible biological pathway between phthalates and birth outcomes.

Objective

Examine associations between 19 maternal urinary phthalate or phthalate replacement metabolites and 9 serum hormones measured over two time points during pregnancy.

Design

Longitudinal study conducted in the PROTECT pregnancy cohort.

Setting

Puerto Rico.

Patients

Six hundred seventy-seven women in the first trimester of pregnancy.

Main outcome measures serum

CRH, estriol, SHBG, progesterone, TSH, total T3, free T4, total T4, and testosterone.

Results

T3 was significantly associated with most metabolites

SUBMITTER: Cathey AL 

PROVIDER: S-EPMC6510018 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature