A gain-of-function sodium channel β2-subunit mutation in painful diabetic neuropathy.

ABSTRACT: Diabetes mellitus is a global challenge with many diverse health sequelae, of which diabetic peripheral neuropathy is one of the most common. A substantial number of patients with diabetic peripheral neuropathy develop chronic pain, but the genetic and epigenetic factors that predispose diabetic peripheral neuropathy patients to develop neuropathic pain are poorly understood. Recent targeted genetic studies have identified mutations in α-subunits of voltage-gated sodium channels (Na_vs) in patients with painful diabetic peripheral neuropathy. Mutations in proteins that regulate trafficking or functional properties of Na_vs could expand the spectrum of patients with Na_v-related peripheral neuropathies. The auxiliary sodium channel β-subunits (β1-4) have been r

SUBMITTER: Alsaloum M 

PROVIDER: S-EPMC6510061 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature