Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism for Brucella abortus.

ABSTRACT: As the causative agent of cattle brucellosis, Brucella abortus commonly exhibits smooth phenotype (by virtue of colony morphology) that is characteristically sensitive to specific Brucella phages, playing until recently a major role in taxonomical classification of the Brucella species by the phage typing approach. We previously reported the discrepancy between traditional phenotypic typing and MLVA results of a smooth phage-resistant (SPR) strain Bab8416 isolated from a 45-year-old custodial worker with brucellosis in a cattle farm. Here, we performed whole genome sequencing and further obtained a complete genome sequence of strain Bab8416 by a combination of multiple NGS technologies and routine PCR sequencing. The detailed genetic differences between B. abortus</

SUBMITTER: Li XM 

PROVIDER: S-EPMC6510165 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature