Effect of Ketoprofen and ATB-352 on the Immature Human Intestine: Identification of Responders and Non-responders.

ABSTRACT:

Background and objective

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a broad spectrum of life-threatening adverse effects on the immature gastrointestinal tract. NSAID derivatives exploiting the beneficial effects of biologically active gases, such as hydrogen sulfide (H2S), have been developed. Herein, we determined the effects of ketoprofen and ATB-352, a H2S-releasing ketoprofen derivative, on selected metabolic pathways previously identified to be significantly altered by indomethacin in the human immature intestine.

Methods

Ketoprofen and ATB-352 were tested on human mid-gestation small intestinal explants maintained in a serum-free organ culture system for 48 hours. The expression levels of the representative genes involved in selected m

SUBMITTER: Thibault MP 

PROVIDER: S-EPMC6510328 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature