The impact of bilateral ongoing activity on evoked responses in mouse cortex.

ABSTRACT: In the absence of external stimuli or overt behavior, the activity of the left and right cortical hemispheres shows fluctuations that are largely bilateral. Here, we show that these fluctuations are largely responsible for the variability observed in cortical responses to sensory stimuli. Using widefield imaging of voltage and calcium signals, we measured activity in the cortex of mice performing a visual detection task. Bilateral fluctuations invested all areas, particularly those closest to the midline. Activity was less bilateral in the monocular region of primary visual cortex and, especially during task engagement, in secondary motor cortex. Ongoing bilateral fluctuations dominated unilateral visual responses, and interacted additively with them, explaining much of the variance in tri

SUBMITTER: Shimaoka D 

PROVIDER: S-EPMC6510533 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature