Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability.

ABSTRACT: Cancer cell metabolism is heavily influenced by microenvironmental factors, including nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential to understand tumor metabolism. To measure the extracellular nutrient levels available to tumors, we utilized quantitative metabolomics methods to measure the absolute concentrations of >118 metabolites in plasma and tumor interstitial fluid, the extracellular fluid that perfuses tumors. Comparison of nutrient levels in tumor interstitial fluid and plasma revealed that the nutrients available to tumors differ from those present in circulation. Further, by comparing interstitial fluid nutrient levels between autochthonous and transplant models of murine pancreatic and lung adenocarcinoma, we found that tumor type

SUBMITTER: Sullivan MR 

PROVIDER: S-EPMC6510537 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature