Biophysical model-based parameters to classify tumor recurrence from radiation-induced necrosis for brain metastases.

ABSTRACT: PURPOSE:Stereotactic radiosurgery (SRS) is used for local control treatment of patients with intracranial metastases. As a result of SRS, some patients develop radiation-induced necrosis. Radiographically, radiation-induced necrosis can appear similar to tumor recurrence in magnetic resonance (MR) T1 -weighted contrast-enhanced imaging, T2 -weighted MR imaging, and Fluid-Attenuated Inversion Recovery (FLAIR) MR imaging. Radiographic ambiguities often necessitate invasive brain biopsies to determine lesion etiology or cause delayed subsequent therapy initiation. We use a biomechanically coupled tumor growth model to estimate patient-specific model parameters and model-derived measures to noninvasively classify etiology of enhancing lesions in this patient population. METHODS:In this initial

SUBMITTER: Narasimhan S 

PROVIDER: S-EPMC6510636 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature