Simultaneous assessment of cell morphology and adhesion using aluminum nanoslit-based plasmonic biosensing chips.

ABSTRACT: A variety of physiological and pathological processes rely on cell adhesion, which is most often tracked by changes in cellular morphology. We previously reported a novel gold nanoslit-based biosensor that is capable of real-time and label-free monitoring of cell morphological changes and cell viability. However, the preparation of gold biosensors is inefficient, complicated and costly. Recently, nanostructure-based aluminum (Al) sensors have been introduced for biosensing applications. The Al-based sensor has a longer decay length and is capable of analyzing large-sized mass such as cells. Here, we developed two types of double-layer Al nanoslit-based plasmonic biosensors, which were nanofabricated and used to evaluate the correlation between metastatic potency and adhesion of lung cancer

SUBMITTER: Hou HS 

PROVIDER: S-EPMC6510726 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature