Contaminated feed-borne Bacillus cereus aggravates respiratory distress post avian influenza virus H9N2 infection by inducing pneumonia.

ABSTRACT: Avian influenza virus subtype H9N2 is identified in chickens with respiratory disease while Bacillus cereus (B. cereus) has been frequently isolated from chicken feed in China. However, the roles of co-infection with these two pathogens remain unclear. In the present study, SPF chicks were intragastrically administered with 10⁸ CFU/mL of B. cereus for 7 days and then inoculated intranasally with 100 EID₅₀ of H9N2 three days later. Alternatively, chickens were initially inoculated with H9N2 and then with B. cereus for one week. Post administration, typical respiratory distress persisted for 5 days in both co-infection groups. Gizzard erosions developed in the groups B. cereus/H9N2 and B. cereus group on 7^th day while in group H9N2/B. cereus on 14^th

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6510747 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature