Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone.

ABSTRACT: Developing clinical tools that assess bone matrix quality could improve the assessment of a person's fracture risk. To determine whether Raman spectroscopy (RS) has such potential, we acquired Raman spectra from human cortical bone using microscope- and fiber optic probe-based Raman systems and tested whether correlations between RS and fracture toughness properties were statistically significant. Calculated directly from intensities at wavenumbers identified by second derivative analysis, Amide I sub-peak ratio I₁₆₇₀/I₁₆₄₀, not I₁₆₇₀/I₁₆₉₀, was negatively correlated with K_init (N = 58; R² = 32.4%) and J-integral (R² = 47.4%) when assessed by Raman micro-spectroscopy. Area ratios (A₁₆₇₀/A₁₆₉₀

SUBMITTER: Unal M 

PROVIDER: S-EPMC6510799 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature