Regional bedrock geochemistry associated with podoconiosis evaluated by multivariate analysis.

ABSTRACT: Podoconiosis is a disease whose etiology remains murky. Currently, the disease is attributed to particles that are believed to move through the skin and into the lymphatic system causing swelling of the lower legs. Identity of these particles or their composition remains unclear, though the presence of silicon and/or aluminum is often noted and frequently cited as causal agents. We applied multivariate analyses to the bedrock compositions of a large set of cases from an online database in an effort to identify underlying patterns or combinations of relative element abundances associated with podoconiosis-endemic regions. Using a combination of principal component analysis, discriminant function analysis, and ANOVA, we analyzed ten oxides from five regions on the African continent known to

SUBMITTER: Cooper JN 

PROVIDER: S-EPMC6510837 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature