Multiparametric whole-body 3.0-T MRI in newly diagnosed intermediate- and high-risk prostate cancer: diagnostic accuracy and interobserver agreement for nodal and metastatic staging.

ABSTRACT:

Objectives

To determine the diagnostic accuracy and interobserver concordance of whole-body (WB)-MRI, vs. ^99mTc bone scintigraphy (BS) and ¹⁸fluoro-ethyl-choline (¹⁸F-choline) PET/CT for the primary staging of intermediate/high-risk prostate cancer.

Methods

An institutional review board approved prospective cohort study carried out between July 2012 and November 2015, whereby 56 men prospectively underwent 3.0-T multiparametric (mp)-WB-MRI in addition to BS (all patients) ± ¹⁸F-choline PET/CT (33 patients). MRI comprised pre- and post-contrast modified Dixon (mDixon), T2-weighted (T2W) imaging, and diffusion-weighted imaging (DWI). Patients underwent follow-up mp-WB-MRI at 1 year to derive the reference standard. WB-MRIs were revie

SUBMITTER: Johnston EW 

PROVIDER: S-EPMC6510859 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature