Repeatability and reproducibility of FreeSurfer, FSL-SIENAX and SPM brain volumetric measurements and the effect of lesion filling in multiple sclerosis.

ABSTRACT:

Objectives

To compare the cross-sectional robustness of commonly used volumetric software and effects of lesion filling in multiple sclerosis (MS).

Methods

Nine MS patients (six females; age 38±13 years, disease duration 7.3±5.2 years) were scanned twice with repositioning on three MRI scanners (Siemens Aera 1.5T, Avanto 1.5T, Trio 3.0T) the same day. Volumetric T₁-weighted images were processed with FreeSurfer, FSL-SIENAX, SPM and SPM-CAT before and after 3D FLAIR lesion filling with LST. The whole-brain, grey matter (GM) and white matter (WM) volumes were calculated with and without normalisation to the intracranial volume or FSL-SIENAX scaling factor. Robustness was assessed using the coefficient of variation (CoV).

Results

Variability in volumetrics was

SUBMITTER: Guo C 

PROVIDER: S-EPMC6510869 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature