Component of splicing factor SF3b plays a key role in translational control of polyribosomes on the endoplasmic reticulum.

ABSTRACT: One of the morphological hallmarks of terminally differentiated secretory cells is highly proliferated membrane of the rough endoplasmic reticulum (ER), but the molecular basis for the high rate of protein biosynthesis in these cells remains poorly documented. An important aspect of ER translational control is the molecular mechanism that supports efficient use of targeted mRNAs in polyribosomes. Here, we identify an enhancement system for ER translation promoted by p180, an integral ER membrane protein we previously reported as an essential factor for the assembly of ER polyribosomes. We provide evidence that association of target mRNAs with p180 is critical for efficient translation, and that SF3b4, an RNA-binding protein in the splicing factor SF3b, functions as a cofactor for p180 at t

SUBMITTER: Ueno T 

PROVIDER: S-EPMC6510990 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature