Pooled analysis suggests benefit of catheter-based hematoma removal for intracerebral hemorrhage.

ABSTRACT:

Objective

To develop models of outcome for intracerebral hemorrhage (ICH) to identify promising and futile interventions based on their early phase results without need for correction for baseline imbalances.

Methods

We developed a pooled outcome model from the control arms of randomized control trials and tested different interventions against the model at comparable baseline conditions. Eligible clinical trials and large case series were identified from multiple library databases. Models based on baseline factors reported in the control arms were tested for the ability to predict functional outcome (modified Rankin Scale score) and mortality. Interventions were grouped into blood pressure control, fibrinolytic-assisted hematoma evacuation, hemostatic medications, and neuro

SUBMITTER: Mandava P 

PROVIDER: S-EPMC6511084 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature