Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank.

ABSTRACT:

Objective

To estimate effects of vitamin D levels on incident delirium hospital admissions using inherited genetic variants in mendelian randomization models, which minimize confounding and exclude reverse causation.

Methods

Longitudinal analysis using the UK Biobank, community-based, volunteer cohort (2006-2010) with incident hospital-diagnosed delirium (ICD-10 F05) ascertained during ≤9.9 years of follow-up of hospitalization records (to early 2016). We included volunteers of European descent aged 60-plus years by end of follow-up. We used single-nucleotide polymorphisms previously shown to increase circulating vitamin D levels, and APOE variants. Cox competing models accounting for mortality were used.

Results

Of 313,121 participants included, 544 were hospi

SUBMITTER: Bowman K 

PROVIDER: S-EPMC6511096 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature