Genome-wide association meta-analysis of functional outcome after ischemic stroke.

ABSTRACT:

Objective

To discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study.

Methods

The study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. The primary outcome was modified Rankin Scale score after 60 to 190 days, evaluated as 2 dichotomous variables (0-2 vs 3-6 and 0-1 vs 2-6) and subsequently as an ordinal variable. GWA analyses were performed in each study independently and results were meta-analyzed. Analyses were adjusted for age, sex, stroke severity (baseline NIH Stroke Scale score), and ancestry. The significance level was p < 5 × 10^-8.

Results

We iden

SUBMITTER: Soderholm M 

PROVIDER: S-EPMC6511098 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature