Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume.

ABSTRACT:

Objective

To investigate the influence of microglial activation in the early stages of Alzheimer's disease trajectory, we assessed the relationship between microglial activation and gray matter volume and hippocampal volume in patients with mild cognitive impairment (MCI).

Methods

In this study, 55 participants (37 with early stages of MCI and 18 controls) underwent [¹¹C]PBR28 PET, a marker of microglial activation; volumetric MRI to evaluate gray matter and hippocampal volumes as well as clinical and neuropsychometric evaluation. [¹¹C]PBR28 V_T (volume of distribution) was calculated using arterial input function and Logan graphical analysis. Gray matter volume and hippocampal volumes were calculated from MRI for each participant. Statistical

SUBMITTER: Femminella GD 

PROVIDER: S-EPMC6511099 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature