Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study.

ABSTRACT:

Objective

To examine the association between systemic inflammation measured during midlife and 20-year cognitive decline.

Methods

Within the Atherosclerosis Risk in Communities cohort study, inflammatory biomarkers were measured during middle adulthood. We created an inflammation composite score using 4 blood biomarkers measured at visit 1 (fibrinogen, white blood cell count, von Willebrand factor, and factor VIII); we measured C-reactive protein (CRP) at visit 2. Cognition was assessed over 3 visits spanning 20 years using measures of memory, executive function, and language.

Results

A total of 12,336 participants (baseline age 56.8 [5.7], 21% black, 56% women) were included. After adjusting for demographic variables, vascular risk factors, and comorbidities, each st

SUBMITTER: Walker KA 

PROVIDER: S-EPMC6511107 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature