Elevated leptin levels induce inflammation through IL-6 in skeletal muscle of aged female rats.

ABSTRACT:

Background

Chronic inflammation with aging contributes to sarcopenia. Previous studies have suggested that the accumulation of adipose tissue in skeletal muscle, referred to as intermuscular adipose tissue (IMAT), increases with age and is associated with inflammation. However, the mechanism governing ectopic inflammation in skeletal muscle due to aging is not fully understood. Leptin, an adipocytokine derived from adipose tissue, is an important mediator of inflammatory processes. We examined changes in leptin levels with age and whether leptin contributes to ectopic inflammation.

Methods

To evaluate ectopic inflammation in skeletal muscle, we measured alterations to the expression of inflammatory cytokine genes (Il1b, Il6, and Tnfa) and muscle break down-related gene (MuRF

SUBMITTER: Tazawa R 

PROVIDER: S-EPMC6511122 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature