Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer.

ABSTRACT:

Background

Breast cancer is the leading cause of cancer related death in women, with metastasis the principle cause of mortality. New non-invasive prognostic markers are needed for the early detection of metastasis, facilitating treatment decision optimisation. MicroRNA (miRNA) are small, non-coding RNAs regulating gene expression and involved in many cellular processes, including metastasis. As biomarkers, circulating miRNAs (in blood) hold great promise for informing diagnosis or monitoring treatment responses.

Methods

Plasma extracted RNA from age matched local Luminal A (n = 4) or metastatic disease (n = 4) were profiled using Next Generation Sequencing. Selected differentially expressed miRNA were validated on a whole blood extracted miRNA cohort [distant metastatic dis

SUBMITTER: McAnena P 

PROVIDER: S-EPMC6511137 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature