Updated Oxford classification and the international study of kidney disease in children classification: application in predicting outcome of Henoch-Schonlein purpura nephritis.

ABSTRACT:

Background

Henoch-Schönlein purpura nephritis (HSPN) shares many similarities with IgA nephropathy. We aimed to analyze the predictive value of the International Study of Kidney Disease in Children (ISKDC) classification and the updated Oxford classification for IgA nephropathy in HSPN patients.

Methods

Data of 275 HSPN patients (aged≥14 years) were retrieved, and all of them underwent a renal biopsy. We re-classified the biopsies according to the ISKDC classification and the updated Oxford classification to analyze their correlations with clinical features and renal outcomes. The renal endpoints were defined as ≥30% reduction in baseline estimated glomerular filtration rate (eGFR) in 2 years, doubling of serum creatinine (Scr) or end stage renal disease.

Results

Duri

SUBMITTER: Huang X 

PROVIDER: S-EPMC6511170 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature