Antioxidative effects of caffeine in a hyperoxia-based rat model of bronchopulmonary dysplasia.

ABSTRACT:

Background

While additional oxygen supply is often required for the survival of very premature infants in intensive care, this also brings an increasing risk of progressive lung diseases and poor long-term lung outcomes. Caffeine is administered to neonates in neonatal intensive care for the prevention and treatment of apneas and has been shown to reduce BPD incidence and the need for mechanical ventilation, although it is still unclear whether this is due to a direct pulmonary action via antagonism of adenosine receptors and/or an indirect action. This experimental study aims to investigate the action of caffeine on the oxidative stress response in pulmonary tissue in a hyperoxia-based model of bronchopulmonary dysplasia in newborn rats.

Methods

Newborn Wistar rats were exp

SUBMITTER: Endesfelder S 

PROVIDER: S-EPMC6511176 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature