Segmentation of medial temporal subregions reveals early right-sided involvement in semantic variant PPA.

ABSTRACT:

Background

Semantic variant of primary progressive aphasia (svPPA) is a subtype of frontotemporal dementia characterized by asymmetric temporal atrophy.

Methods

We investigated the pattern of medial temporal lobe atrophy in 24 svPPA patients compared to 72 controls using novel approaches to segment the hippocampal and amygdalar subregions on MRIs. Based on semantic knowledge scores, we split the svPPA group into 3 subgroups of early, middle and late disease stage.

Results

Early stage: all left amygdalar and hippocampal subregions (except the tail) were affected in svPPA (21-35% smaller than controls), together with the following amygdalar nuclei in the right hemisphere: lateral, accessory basal and superficial (15-23%). On the right, only the temporal pole was affecte

SUBMITTER: Bocchetta M 

PROVIDER: S-EPMC6511178 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature