Experimental necrotizing enterocolitis induces neuroinflammation in the neonatal brain.

ABSTRACT:

Background

Necrotizing enterocolitis (NEC) is an inflammatory gastrointestinal disease primarily affecting preterm neonates. Neonates with NEC suffer from a degree of neurodevelopmental delay that is not explained by prematurity alone. There is a need to understand the pathogenesis of neurodevelopmental delay in NEC. In this study, we assessed the macroscopic and microscopic changes that occur to brain cell populations in specific brain regions in a neonatal mouse model of NEC. Moreover, we investigated the role of intestinal inflammation as part of the mechanism responsible for the changes observed in the brain of pups with NEC.

Methods

Brains of mice were assessed for gross morphology and cerebral cortex thickness (using histology). Markers for mature neurons, oligodendroc

SUBMITTER: Biouss G 

PROVIDER: S-EPMC6511222 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature