Monocyte Subpopulation Recovery as Predictors of Hematopoietic Cell Transplantation Outcomes.

ABSTRACT: Monocyte recovery after hematopoietic cell transplantation (HCT) has been correlated with overall survival (OS). However, monocytes are heterogeneous and consist of classic (CD14⁺⁺CD16^-), intermediate (CD14⁺CD16⁺), and nonclassic (CD14⁺CD16⁺⁺) subpopulations, with unique functional properties. We hypothesized that monocyte subpopulation reconstitution would vary based on allogeneic stem cell source and would be associated with outcomes. We studied monocyte subpopulation recovery at days 28, 60, 100, 180, and 365 post-HCT among 202 patients with hematologic malignancy. Significant differences in absolute monocyte count (AMC) and monocyte subpopulation counts at days 60 and 100 were identified based on stem cell source (all P

SUBMITTER: Turcotte LM 

PROVIDER: S-EPMC6511306 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature