Association between prenatal particulate air pollution exposure and telomere length in cord blood: Effect modification by fetal sex.

ABSTRACT:

Introduction

In utero particulate matter exposure produces oxidative stress that impacts cellular processes that include telomere biology. Newborn telomere length is likely critical to an individual's telomere biology; reduction in this initial telomere setting may signal increased susceptibility to adverse outcomes later in life. We examined associations between prenatal particulate matter with diameter ≤2.5 µm (PM_2.5) and relative leukocyte telomere length (LTL) measured in cord blood using a data-driven approach to characterize sensitive windows of prenatal PM_2.5 effects and explore sex differences.

Methods

Women who were residents of Mexico City and affiliated with the Mexican Social Security System were recruited during pregnancy (n = 423 for analy

SUBMITTER: Rosa MJ 

PROVIDER: S-EPMC6511309 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature