High phthalate exposure increased urinary concentrations of quinolinic acid, implicated in the pathogenesis of neurological disorders: Is this a potential missing link?

ABSTRACT: BACKGROUND:Quinolinic acid (QA), a neuroactive metabolite of the Kynurenine Pathway (KP), is an excitotoxin that is implicated in the pathogenesis of many neurological disorders. KP is the main tryptophan degradation pathway. Phthalates can structurally mimic tryptophan metabolites and diets containing phthalates in rats enhanced the production and excretion of QA. However, there are no human studies that have examined the association between phthalates and QA. OBJECTIVES:Taking advantage of different mesalamine formulations with/without dibutyl phthalate (DBP), we assessed whether DBP from mesalamine (>1000x background) altered the urinary concentrations of QA. METHODS:Men with inflammatory bowel disease participated in a prospective crossover pilot study. 15 Men were on non-DBP mesalamin

SUBMITTER: Nassan FL 

PROVIDER: S-EPMC6511314 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature