Exercise for Depression: A Feasibility Trial Exploring Neural Mechanisms.

ABSTRACT:

Objective

The aim of this study was to test the feasibility of an exercise augmentation to pharmacotherapy in depressed younger and older adults while exploring neural mechanisms.

Methods

A randomized, double-blind, controlled clinical trial was conducted in 15 inactive younger (20-39 years) and older (60-79 years) adults meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for a major depressive episode (https://clinicaltrials.gov/ct2/show/NCT02407704). Participants were randomized to receive a 12-week regimen of venlafaxine XR or venlafaxine XR plus supervised exercise. Cardiorespiratory fitness was assessed using a submaximal Vo₂ test, and neuroimaging assessments were conducted using a Siemans MAGNETOM 7-Tesla magnetic resonan

SUBMITTER: Gujral S 

PROVIDER: S-EPMC6511318 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature