A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.

ABSTRACT: Youth drinking is a pervasive public health concern with serious negative developmental implications. Candidate gene and environment interaction studies (cGxE) show that environmental effects on drinking behaviors may differ by individuals' genotypes. Yet little is known about whether genetic and environmental effects on drinking behaviors are developmentally specific. This systematic review evaluated 42 cGxE studies of drinking in adolescence and young adulthood. Although there are mixed findings, studies of cGxE effects involving DRD4, 5-HTTLPR, DRD2, and OPRM1 genotypes showed relatively consistent patterns. The effects of under-controlled environments (eg, low levels of parental monitoring) on early and middle adolescent drinking appeared to differ across DRD2 or OPRM1 genotypes. Effec

SUBMITTER: Kim J 

PROVIDER: S-EPMC6511325 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature