Central venous pressure value can assist in adjusting norepinephrine dosage after the initial resuscitation of septic shock.

ABSTRACT:

Background

New definitions for sepsis and septic shock (Sepsis-3) were published, but the strategy to adjust vasopressors after the initial guidelines is still unclear. We conducted a retrospective observational study to explore dosing strategy of norepinephrine (NE).

Methods

A retrospective observational study in the 15-bed mixed intensive care unit of a tertiary care university hospital. The study was performed on septic shock patients after 30 mL/kg fluid resuscitation and mean arterial pressure (MAP) levels reached >65 mmHg requiring NE. We divided patients into NE dosage increase and decrease groups, and collected hemodynamic and tissue perfusion parameters before (T1) and after (T2) adjusting NE dosage.

Results

In both NE increase and decrease groups, central ve

SUBMITTER: Li DK 

PROVIDER: S-EPMC6511425 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature