Dataset Information
Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr).
Ontology highlight
ABSTRACT: Introduction
A small percentage of Alzheimer's disease (AD) cases are caused by genetic mutations with autosomal dominant inheritance. We report a family with a novel variant in PSEN1.Methods
We performed clinical and genetic evaluation of 93 related individuals from a Colombian admixed population. 31 individuals had whole-genome sequencing.Results
Genetic analysis revealed a missense variant in PSEN1 (NM_000021.3: c.1247T>C p.Ile416Thr), which originated on an African haplotype and segregated with AD logarithm of the odds score of 6. Their clinical phenotype is similar to sporadic AD except for earlier age at onset: the mean age at onset for mild cognitive impairment was 47.6 years (standard deviation 5.83) and for dementia 51.6 years (standard deviation 5.03).Discussion
Ile416Thr is a novel pathogenic variant that causes AD in the sixth decade of life. The history of the region that included slave importation and admixtures within a confined geographic locale represents a "mini-population bottleneck" and subsequent emergence of a rare dominant mutation.
SUBMITTER: Ramirez Aguilar L
PROVIDER: S-EPMC6511480 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr).
Alzheimer's & dementia : the journal of the Alzheimer's Association 20190210 5
<h4>Introduction</h4>A small percentage of Alzheimer's disease (AD) cases are caused by genetic mutations with autosomal dominant inheritance. We report a family with a novel variant in PSEN1.<h4>Methods</h4>We performed clinical and genetic evaluation of 93 related individuals from a Colombian admixed population. 31 individuals had whole-genome sequencing.<h4>Results</h4>Genetic analysis revealed a missense variant in PSEN1 (NM_000021.3: c.1247T>C p.Ile416Thr), which originated on an African ha ...[more]