Common variants at 5q33.1 predispose to migraine in African-American children.

ABSTRACT:

Background

Genome-wide association studies (GWASs) have identified multiple susceptibility loci for migraine in European adults. However, no large-scale genetic studies have been performed in children or African Americans with migraine.

Methods

We conducted a GWAS of 380 African-American children and 2129 ancestry-matched controls to identify variants associated with migraine. We then attempted to replicate our primary analysis in an independent cohort of 233 African-American patients and 4038 non-migraine control subjects.

Results

The results of this study indicate that common variants at 5q33.1 associated with migraine risk in African-American children (rs72793414, p=1.94×10^-9). The association was validated in an independent study (p=3.87×10^-3

SUBMITTER: Chang X 

PROVIDER: S-EPMC6511513 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature