Association of High Intakes of Vitamins B6 and B12 From Food and Supplements With Risk of Hip Fracture Among Postmenopausal Women in the Nurses' Health Study.

ABSTRACT:

Importance

Vitamin supplementation far exceeding recommended doses is popular in segments of the population. However, adverse effects can occur. In a previous secondary analysis of combined data from 2 double-blind randomized clinical trials (RCTs), an unexpected increased risk of hip fracture was found among those treated with high doses of vitamin B6 in combination with vitamin B12.

Objectives

To study if high intakes of vitamins B6 and B12 from food and supplements were associated with a risk of hip fracture in the Nurses' Health Study and to investigate whether combined high intakes of both vitamins conferred a particularly increased fracture risk.

Design, setting, and participants

In this prospective cohort study, 75 864 postmenopausal women in the United States

SUBMITTER: Meyer HE 

PROVIDER: S-EPMC6512300 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature