Obesity and Longer Term Risks of Dementia in 65-74 Year Olds.

ABSTRACT: BACKGROUND:overweight or obesity at ages <65 years associates with increased dementia incidence, but at ≥65 years estimates are paradoxical. Weight loss before dementia diagnosis, plus smoking and diseases causing weight loss may confound associations. OBJECTIVE:to estimate weight loss before dementia diagnosis, plus short and longer-term body mass index associations with incident dementia in 65-74 year olds within primary care populations in England. METHODS:we studied dementia diagnosis free subjects: 257,523 non-smokers without baseline cancer, heart failure or multi-morbidity (group A) plus 161,927 with these confounders (group B), followed ≤14.9 years. Competing hazard models accounted for mortality. RESULTS:in group A, 9,774 were diagnosed with dementia and in those with repeat weigh

SUBMITTER: Bowman K 

PROVIDER: S-EPMC6512743 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature