Surface modulation of single-walled carbon nanotubes for selective bacterial cell agglutination.

ABSTRACT:

Background

Bacterial resistance to antibiotics is one of the biggest challenges facing medicine today. Anti-adhesive therapy, using inhibitors of bacterial adhesion to epithelial cells, one of the first stages of infection, is a promising approximation in this area. The size, shape, number of sugar and their placement are variables that have to be taken into account in order to develop multivalent systems able to inhibit the bacterial adhesion based on sugar-lectin interaction.

Materials and methods

In the present work we report a modular approach for the synthesis of water-soluble 1D-carbon nanotube-sugar nanoconstructs, with the necessary flexibility to allow an efficient sugar-lectin interaction. The method is based on the reaction of aryl diazonium salts generated in sit

SUBMITTER: Romero-Ben E 

PROVIDER: S-EPMC6512782 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature